ABSTRACT
Objective To study the clinical efficacy of viable bifidobacterium combined with montmorillonite powder in the treatment of infantile diarrhea.Methods 100 patients with infantile diarrhea disease were randomly divided into control group and observation group,50 cases in each group.The control group was given montmorillonitc powder treatment,while the observation group was added viable bifidobacterium treatment based on control group.Effi-cacy,serum C reactive protein (CRP)level,clinical symptom improvement time and adverse reactions rate were com-pared between two groups.Results The total effective rates of clinical treatment in the control group and observation group were 78%(39 /50)and 96%(48 /50)(P1 =0.026).After treatment,the treatment time,diarrhea stopping time,body temperature returned to normal,frequency of defecate recovery time,shape of defecate recovery time and scrum CRP levels in the control group were (8.73 ±1.92)d,(2.32 ±0.85)d,(27.53 ±7.24)h,(2.52 ±0.85)d, (3.62 ±1.23)d and (13.63 ±2.15)mg/L,which in observation group were (6.15 ±1.26)d,(1.53 ±0.62)d, (19.65 ±5.71)h,(1.75 ±0.76)d,(2.56 ±0.85)d and (7.52 ±1.26)mg/L.The observation group were better than the control group (P2 =0.026,P3 =0.018,P4 =0.021,P5 =0.012,P6 =0.031,P10 =0.002).The incidence of adverse reactions between two groups had no obvious difference.Conclusion Viable bifidobacterium combined with montmorillonite powder can effectively treat infantile diarrhea,with advantages of significant clinical efficacy,quickly recovery of clinical symptoms,rapidly reduce of CRP level,and low adverse reactions,it is worthy of promotion.
ABSTRACT
Objective To discuss the relationship between TCM syndromes and peritoneal fluid cytokine IL-6, IL-8 and TNF-α of endometriosis infertility patients, and provide thoughts for clinical treatment. Methods Totally 105 patients of endometriosis infertility were differentiated to six syndrome groups, including kidney deficiency and blood stasis, qi stagnation and blood stasis, heat stagnation and blood stasis, cold congelation and blood stasis, qi deficiency and blood stasis, phlegm-dampness stagnation. Thirty patients of non-endometriosis infertility were selected as control group. Enzyme-linked immunosorbent assay was used to detect cytokine levels of IL-6, IL-8 and TNF-α. Results In 105 cases of EM infertility, 35 cases (33.33%) were syndrome of kidney deficiency and blood stasis, 22 cases (20.95%) were syndrome of cold congelation and blood stasis, 18 cases (17.14%) were syndrome of qi stagnation and blood stasis, 10 cases (9.52%) were syndrome of heat stagnation and blood stasis, 11 cases (10.48%) were syndrome of qi deficiency and blood stasis, 9 cases (8.57%) were phlegm-dampness stagnation syndrome. The levels of IL-6, IL-8 and TNF-αin each syndrome group of EM infertility were higher than control group (P<0.01). IL-6 level in kidney deficiency and blood stasis group were higher than other syndrome groups (P<0.05). The levels of IL-8 and TNF-α in kidney deficiency and blood stasis group, and heat stagnation and blood stasis group were higher than other syndrome groups (P<0.05). IL-8 in kidney deficiency and blood stasis group was higher than that in heat stagnation and blood stasis group (P<0.05). Conclusion TCM syndromes in patients with endometriosis infertility have some relevance with peritoneal fluid cytokine levels of IL-6, IL-8, TNF-α, which may guide clinical understanding and treatment of endometriosis infertility.